The therapeutic effects of chicory seed aqueous extract on cardio-metabolic profile and liver enzymes in nonalcoholic fatty liver disease; a double blind randomized clinical trial

Introduction: As diabetes and obesity increase worldwide, non-alcoholic fatty liver disease (NAFLD) becomes a more worrying health threat. Objectives: This study was designed to assess the impacts of chicory seed aqueous extract on treatment NAFLD. Patients Methods: Around 60 patients with NAFLD who referred Zanjan Metabolic Disease Research Center between March 2016 April 2017 were allocated into placebo groups, randomly. The participants in group (n=30) scheduled consume 8 ml syrup (made by soaking 100 g dried seeds one liter boiling water) twice daily for 12 weeks. control group’s received an identical figure flavor also same prescript. analysis covariance (ANCOVA) test, chi-square independent t-test paired t test applied data. From point statistical view, P < 0.05 considered significant. Results: body mass index (BMI), enzymes, fasting blood sugar (FBS), HbA1c, grading all indices lipid profile decreased significantly (all values 0.001) group. shifting change striking compared controls. Conclusion: findings this support application due ameliorative effects metabolic disease. Trial Registration: clinical trial protocol has been registered Iranian Registry Clinical (identifier: IRCT2016061228411N1; https://en.irct.ir/trial/23063, ethical code #IR.ZUMS.REC.1395.195).